Compound Index
NAD+ and Skeletal Muscle Research: Metabolism, Atrophy Prevention, and Protocol Design
A comprehensive research guide covering NAD+ mechanisms in skeletal muscle — SIRT1/SIRT3 substrate targets, NAMPT salvage pathway, muscle atrophy prevention (MuRF-1/Atrogin-1), mitochondrial biogenesis, glucose uptake, and published preclinical protocols for aging muscle research.
SIRT1 and SIRT3: The NAD⁺-Dependent Sirtuin Research Guide
A comprehensive research guide to sirtuin biology: SIRT1 nuclear deacetylase targets (PGC-1α, p53, NF-κB, FOXO3a, BDNF promoter IV), SIRT3 mitochondrial targets (SOD2, IDH2, LCAD, PDHA1), NAD⁺ substrate dependency, compound modulation data, and full study design protocols for longevity and metabolic research.
NAD+ and DNA Repair: PARP1, Sirtuins, and Genome Stability Research Protocols
A deep-dive into how NAD+ fuels PARP1-mediated DNA repair and sirtuin-dependent chromatin maintenance. Covers PARP1/SIRT1 competition, SIRT6 DSB repair scaffolding, NMN rescue protocols, comet assay and γH2AX foci methods, and research design considerations for genome stability studies.