Research Tools · Pharmacokinetics

Peptide Half-Life Reference Table

Fast-load pharmacokinetic reference for 32+ research peptides. Half-life, peak time (T_max), recommended dosing frequency, and administration route — all sourced from published PK studies. For interactive decay modeling, use the Half-Life Calculator.

Long (≥24h)Medium (4–24h)Short (1–4h)Ultra-short (<1h)

Jump to:GLP-1 / Metabolic GH Secretagogues Recovery & Healing Longevity / Anti-Aging Cognitive / Nootropic Hormonal / Endocrine Immunology Cosmetic / Topical ↓ Full Table

GLP-1 / Metabolic

4 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
Semaglutide Long (≥24h)	~168 h (7 days)	24–72 h	SC	Once weekly	Marbury 2017, Kapitza 2012	View →
Retatrutide Long (≥24h)	~144 h (6 days)	24–72 h	SC	Once weekly	Jastreboff 2023 NEJM	View →
Tirzepatide Long (≥24h)	~120 h (5 days)	8–72 h	SC	Once weekly	Frias 2021 NEJM, Coskun 2022	View →
AOD-9604 Ultra-short (<1h)	~30 min	15–30 min	SC / IP	Once or twice daily	Heffernan 1999, Ng 2000	View →

GH Secretagogues

10 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
CJC-1295 with DAC Long (≥24h)	~192 h (8 days)	6–12 h	SC	Once or twice weekly	Jetté 2005, Thornton 2010	View →
MK-677 (Ibutamoren) Long (≥24h)	~24 h	2–4 h (oral)	Oral	Once daily	Nass 2008, Copinschi 1997	View →
Ipamorelin Short (1–4h)	~2 h	15–30 min	SC / IV	3× daily or nightly	Johansen 1999, Arvat 1997	View →
CJC-1295 / Ipamorelin Blend Short (1–4h)	Dual: 30 min + 2 h	15–30 min (ipa); 5–15 min (CJC No DAC)	SC	3× daily or nightly	Bowers 1998 (synergy data)	View →
Hexarelin Short (1–4h)	~1.5–2 h	15–30 min	SC / IV	3× daily	Ghigo 1994, Bodart 1999	View →
GHRP-2 (Pralmorelin) Short (1–4h)	~1.5 h	15–30 min	SC / IV	3× daily	Arvat 1997, Bowers 1984	View →
GHRP-6 Short (1–4h)	~1.5 h	15–30 min	SC / IV	3× daily	Bowers 1990 JCEM	View →
CJC-1295 No DAC (Mod GRF 1-29) Ultra-short (<1h)	~30 min	5–15 min	SC / IV	3× daily (pulsatile)	Walker 2021, Bowers 1998	View →
Tesamorelin Ultra-short (<1h)	~26–30 min	10–20 min	SC	Once daily	Lo 2010 NEJM, Bhutani 2022	View →
Sermorelin Ultra-short (<1h)	~11–12 min	5–10 min	SC / IV	Daily (nightly pre-sleep)	Vittone 1997, Sigalos 2018	View →

Recovery & Healing

4 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
TB-500 (Thymosin β4) Medium (4–24h)	~8 h	1–2 h	SC / IM	2–3× weekly	Bock-Marquette 2004, Ehrlich 2010	View →
BPC-157 Medium (4–24h)	~4 h	30–60 min	SC / IP / Oral	Once or twice daily	Sikiric 2014, Sever 2014	View →
KPV Short (1–4h)	~1 h	15–30 min	SC / IP / Oral	Once or twice daily	Dalmasso 2008, Mandal 2009	View →
GHK-Cu Ultra-short (<1h)	~30 min	15–30 min	SC / Topical	Once daily	Pickart 2015, Leyden 2004	View →

Longevity / Anti-Aging

4 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
Epitalon Short (1–4h)	~1 h	15–30 min	SC / IP	Pulsatile 10-day courses	Khavinson 2003, Anisimov 2003	View →
MOTS-c Ultra-short (<1h)	~30 min	15–30 min	IP / SC	Daily or 5×/week	Lee 2015 Cell Metabolism	View →
SS-31 (Elamipretide) Ultra-short (<1h)	~30 min	15–30 min	SC / IV	Daily or acute dosing	Szeto 2008, Siegel 2013	View →
NAD+ (IV) Ultra-short (<1h)	~2 min	End of infusion	IV / IP	Per study protocol	Pencina 2023, Gomes 2013	View →

Cognitive / Nootropic

3 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
DSIP Ultra-short (<1h)	~30 min	15–30 min	IV / SC	Pre-sleep dosing	Monnier 1977, Kovalzon 1991	View →
Semax Ultra-short (<1h)	~10–15 min	5–15 min	IN / SC	1–2× daily	Dolotov 2006, Agapova 2007	View →
Selank Ultra-short (<1h)	~8–10 min	5–15 min	IN / SC	1–3× daily	Kozlovskaya 2002, Semenova 2010	View →

Hormonal / Endocrine

4 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
PT-141 (Bremelanotide) Short (1–4h)	~2.7 h	1–2 h	SC / IN	As needed (study protocol)	Kingsberg 2019, Diamond 2004	View →
Melanotan II Short (1–4h)	~1 h	30–60 min	SC / IN	Once daily	Dorr 1998, Wessells 1998	View →
Kisspeptin-10 Ultra-short (<1h)	~5 min	2–10 min (IV)	IV / SC / IP	Pulsatile (per study)	Dhillo 2005 JCEM, Abbara 2017	View →
Oxytocin Ultra-short (<1h)	~5 min	1–5 min (IN)	IN / IP / IV	Per behavioral study	Neumann 2013, Striepens 2013	View →

Immunology

2 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
Thymosin Alpha-1 (Tα1) Short (1–4h)	~2 h	30–60 min	SC	Twice weekly	Garaci 2012, Zhao 2020 CID	View →
LL-37 Short (1–4h)	~1–2 h	30–60 min	SC / IP / Topical	Once daily	Guaní-Guerra 2010, Torossian 2009	View →

Cosmetic / Topical

1 compounds

Compound	Half-Life	T_max	Route	Frequency	Source	Product
Snap-8 (Acetyl Octapeptide-3) Short (1–4h)	~1–2 h (topical)	N/A (topical application)	Topical	Twice daily (topical)	Lupo 2012, cosmetic research	View →

All Compounds Ranked by Half-Life

Sorted longest to shortest. Useful for washout period planning and multi-compound stacking.

#	Compound	Category	Half-Life	T_max	Route	Frequency
1	CJC-1295 with DAC	GH Secretagogues	~192 h (8 days)	6–12 h	SC	Once or twice weekly
2	Semaglutide	GLP-1 / Metabolic	~168 h (7 days)	24–72 h	SC	Once weekly
3	Retatrutide	GLP-1 / Metabolic	~144 h (6 days)	24–72 h	SC	Once weekly
4	Tirzepatide	GLP-1 / Metabolic	~120 h (5 days)	8–72 h	SC	Once weekly
5	MK-677 (Ibutamoren)	GH Secretagogues	~24 h	2–4 h (oral)	Oral	Once daily
6	TB-500 (Thymosin β4)	Recovery & Healing	~8 h	1–2 h	SC / IM	2–3× weekly
7	BPC-157	Recovery & Healing	~4 h	30–60 min	SC / IP / Oral	Once or twice daily
8	PT-141 (Bremelanotide)	Hormonal / Endocrine	~2.7 h	1–2 h	SC / IN	As needed (study protocol)
9	Ipamorelin	GH Secretagogues	~2 h	15–30 min	SC / IV	3× daily or nightly
10	Thymosin Alpha-1 (Tα1)	Immunology	~2 h	30–60 min	SC	Twice weekly
11	CJC-1295 / Ipamorelin Blend	GH Secretagogues	Dual: 30 min + 2 h	15–30 min (ipa); 5–15 min (CJC No DAC)	SC	3× daily or nightly
12	Hexarelin	GH Secretagogues	~1.5–2 h	15–30 min	SC / IV	3× daily
13	GHRP-2 (Pralmorelin)	GH Secretagogues	~1.5 h	15–30 min	SC / IV	3× daily
14	GHRP-6	GH Secretagogues	~1.5 h	15–30 min	SC / IV	3× daily
15	LL-37	Immunology	~1–2 h	30–60 min	SC / IP / Topical	Once daily
16	Snap-8 (Acetyl Octapeptide-3)	Cosmetic / Topical	~1–2 h (topical)	N/A (topical application)	Topical	Twice daily (topical)
17	KPV	Recovery & Healing	~1 h	15–30 min	SC / IP / Oral	Once or twice daily
18	Epitalon	Longevity / Anti-Aging	~1 h	15–30 min	SC / IP	Pulsatile 10-day courses
19	Melanotan II	Hormonal / Endocrine	~1 h	30–60 min	SC / IN	Once daily
20	AOD-9604	GLP-1 / Metabolic	~30 min	15–30 min	SC / IP	Once or twice daily
21	CJC-1295 No DAC (Mod GRF 1-29)	GH Secretagogues	~30 min	5–15 min	SC / IV	3× daily (pulsatile)
22	GHK-Cu	Recovery & Healing	~30 min	15–30 min	SC / Topical	Once daily
23	MOTS-c	Longevity / Anti-Aging	~30 min	15–30 min	IP / SC	Daily or 5×/week
24	SS-31 (Elamipretide)	Longevity / Anti-Aging	~30 min	15–30 min	SC / IV	Daily or acute dosing
25	DSIP	Cognitive / Nootropic	~30 min	15–30 min	IV / SC	Pre-sleep dosing
26	Tesamorelin	GH Secretagogues	~26–30 min	10–20 min	SC	Once daily
27	Semax	Cognitive / Nootropic	~10–15 min	5–15 min	IN / SC	1–2× daily
28	Sermorelin	GH Secretagogues	~11–12 min	5–10 min	SC / IV	Daily (nightly pre-sleep)
29	Selank	Cognitive / Nootropic	~8–10 min	5–15 min	IN / SC	1–3× daily
30	Kisspeptin-10	Hormonal / Endocrine	~5 min	2–10 min (IV)	IV / SC / IP	Pulsatile (per study)
31	Oxytocin	Hormonal / Endocrine	~5 min	1–5 min (IN)	IN / IP / IV	Per behavioral study
32	NAD+ (IV)	Longevity / Anti-Aging	~2 min	End of infusion	IV / IP	Per study protocol

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Research Use Only. All pharmacokinetic data on this page is sourced from peer-reviewed published literature and is provided for research reference purposes only. Half-life values may vary based on species, route of administration, formulation, and individual subject characteristics. This page does not constitute medical advice, clinical guidance, or recommendations for human use. All compounds listed are for laboratory research use only by qualified researchers in accordance with applicable federal, state, and local regulations.