Category
Nootropics
13 articles
Oxytocin for Social Behavior and Autism Research: OTR Pharmacology, Circuits, and Protocol Design
A comprehensive preclinical research guide covering oxytocin receptor pharmacology, hypothalamic-limbic social circuits, published behavioral data, intranasal vs IP delivery comparison, and full study design protocols for autism spectrum disorder, social memory, and anxiety research models.
Selank for Anxiety and Stress Research: Mechanisms, Protocols, and Study Design
A deep-dive into Selank's anxiolytic mechanisms — presynaptic GABA enhancement, BDNF upregulation, IL-6/IL-8 normalization, and tuftsin pharmacology. Includes intranasal vs IP delivery comparison, behavioral assay protocols, and research design considerations.
Semax for Cognitive Enhancement and Neuroprotection: Mechanisms, Protocols, and Study Design
A comprehensive research guide to Semax — ACTH(4-7)PGP pharmacology, BDNF/VEGF upregulation mechanisms, cognitive and neuroprotective preclinical data, intranasal vs IP delivery, and full study design considerations for nootropic and stroke research.
Peptide Research for Cognitive Aging: BDNF, mTOR, and the Multi-Compound Protocol Approach
A comprehensive research guide covering the molecular mechanisms of cognitive aging and how research peptides — Semax, Selank, NAD+, GHK-Cu, SS-31, and GLP-1 agonists — target different nodes in the neurodegeneration cascade.
Peptide Research for Depression, Mood, and Stress: Selank, Semax, BPC-157, and NAD+ Protocol Design
A comprehensive research protocol guide for studying depression, mood disorders, and stress biology with peptides. Covers Selank, Semax, BPC-157, and NAD+ mechanisms, validated behavioral models, endpoint selection, and multi-compound study design.
Peptide Research for Sleep and Circadian Rhythms: DSIP, MK-677, and Epitalon
A comprehensive research guide covering the three main peptide classes that interact with sleep architecture and circadian biology — DSIP, MK-677, and Epitalon — with mechanisms, published polysomnographic data, preclinical dosing protocols, and study design considerations.
Peptide Research for Sleep: DSIP, GH Secretagogues, and Circadian Biology
A comprehensive research guide to peptides that influence sleep architecture, GH pulse timing, and circadian rhythms — DSIP, ipamorelin, sermorelin, Epitalon, and oxytocin. Includes study design, circadian timing requirements, dosing protocols, and polysomnography endpoints.
Peptide Research for Neuroprotection: BDNF, GDNF, and Neurotrophic Signaling
Deep dive into neurotrophic signaling in peptide research: how BPC-157, Selank, Semax, GLP-1 agonists, and NAD+ modulate BDNF, GDNF, and TrkB/RET receptor pathways. Includes rodent model selection, endpoint design, and research protocol guidance.
Selank & Semax: Nootropic Peptide Research Overview
A comparative review of two Russian nootropic peptides: Selank (tuftsin analog) and Semax (ACTH(4-7)PGP analog). Covers anxiolytic mechanisms, BDNF/VEGF upregulation, IL-6 modulation, and head-to-head mechanism comparison.
Oxytocin: The Research Neuropeptide
A research-focused guide to oxytocin — hypothalamic synthesis, OTR receptor Gq/PKC signaling, social behavior circuits, HPA axis dampening, pain modulation, intranasal delivery pharmacokinetics, murine dosing protocols, and research design considerations.
DSIP (Delta Sleep-Inducing Peptide): Sleep Research Review
A research-oriented review of Delta Sleep-Inducing Peptide (DSIP): discovery, structure, EEG delta-wave promotion, HPA axis modulation, antioxidant properties, and preclinical dosing protocols.
Cerebrolysin: Neurotrophic Peptide Research Review
A comprehensive research review of Cerebrolysin — its porcine-derived peptide composition, BDNF/NGF mimetic neurotrophic activity, GAP-43 upregulation, apoptosis inhibition, and data from stroke recovery, Alzheimer's disease, and TBI clinical trials.
Adamax (DSIP + Selank + NAD+): Nootropic Protocol Deep Dive
A research-oriented deep dive into the Adamax nootropic stack: DSIP (sleep/SWS induction), Selank (anxiolytic/BDNF/IL-6 modulation), and NAD+ (SIRT1/SIRT3 neuroprotection/mitochondrial function). Covers non-competing mechanisms, temporal protocol design, published data for each compound, and combination research design considerations.