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Research Literature

Peptide Research News Feed

Curated landmark and high-impact papers from PubMed and major journals. Filter by compound, category, or impact level. Updated with each site build.

24 curated papers·11 landmark studies·20 compounds covered·Sourced from PubMed · Nature · NEJM

Showing 24 of 24 papers

Landmark2021GLP-1 AxisMetabolic Research
New England Journal of Medicine

Once-Weekly Semaglutide in Adults with Overweight or Obesity

Wilding JPH, Batterham RL, Calanna S, et al. (STEP 1 Study Group)

Key Finding:−14.9% body weight at 68 weeks; 86% achieved ≥5% weight loss
PubMed 33567185DOI: 10.1056/NEJMoa2032183
Landmark2022GLP-1 AxisMetabolic Research
New England Journal of Medicine

Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)

Jastreboff AM, Aronne LJ, Ahmad NN, et al.

Key Finding:−20.9% body weight at 72 weeks; 57% achieved ≥20% reduction at 15 mg
PubMed 35658024DOI: 10.1056/NEJMoa2206038
Landmark2023GLP-1 AxisMetabolic Research
New England Journal of Medicine

Triple Hormone Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

Jastreboff AM, Kaplan LM, Frías JP, et al.

Key Finding:−24.2% body weight at 48 weeks; 26% achieved ≥30% weight loss — highest ever reported
PubMed 37354040DOI: 10.1056/NEJMoa2301972
Landmark2023GLP-1 AxisCardiovascular
New England Journal of Medicine

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)

Lincoff AM, Brown-Frandsen K, Colhoun HM, et al.

Key Finding:20% MACE reduction (HR 0.80) independent of weight loss magnitude
PubMed 37952131DOI: 10.1056/NEJMoa2307563
Landmark2018Repair PeptidesGI Research
Frontiers in Pharmacology

Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

Sikirić P, Seiwerth S, Rucman R, et al.

Key Finding:Consistent repair effects in 25+ years of rodent models across multiple tissues via NO/eNOS/VEGF/EGR-1
PubMed 29706893DOI: 10.3389/fphar.2018.00000
Landmark2004Repair PeptidesCardiovascular
Nature

Thymosin β4 Activates Integrin-Linked Kinase and Promotes Cardiac Cell Migration, Survival and Cardiac Repair

Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D.

Key Finding:Tβ4 → ILK → Akt: reduced infarct size and preserved ejection fraction in MI mice
PubMed 15215858DOI: 10.1038/nature02557
Landmark2013LongevityMitochondrial
Cell

Declining NAD⁺ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes AP, Price NL, Ling AJY, et al.

Key Finding:NMN 500 mg/kg/day IP reversed age-related mitochondrial dysfunction within one week
PubMed 24360282DOI: 10.1016/j.cell.2013.11.037
High2008GH AxisLongevity
Annals of Internal Medicine

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

Nass R, Pezzoli SS, Oliveri MC, et al.

Key Finding:25 mg oral MK-677: +39.9% IGF-1, +1.1 kg lean mass over 2 years; glucose/insulin modest rise
PubMed 18779586DOI: 10.7326/0003-4819-149-9-200811040-00003
Landmark1999GH Axis
European Journal of Endocrinology

Ipamorelin, the First Selective Growth Hormone Secretagogue

Johansen PB, Segev Y, Landau H, et al.

Key Finding:First selective GHRP: GH elevation without cortisol/ACTH/prolactin activation; low tachyphylaxis
PubMed 10078852DOI: 10.1530/eje.0.1400000
High2003Longevity
Bulletin of Experimental Biology and Medicine

Tetrapeptide Epitalon Regulates Telomerase Activity and Telomere Length in Human Somatic Cells

Khavinson VKh, Bondarev IE, Butyugov AA.

Key Finding:2.4× telomerase activation; 200-500 bp telomere elongation in human fetal fibroblasts
PubMed 12802085DOI: 10.1023/A:1024585722666
High2008Repair PeptidesLongevity
Journal of Biomaterials Science, Polymer Edition

The Human Tri-Peptide GHK and Tissue Remodeling

Pickart L.

Key Finding:GHK-Cu regulates 2,000+ genes; activates TGF-β collagen synthesis, Nrf2 antioxidant, and resets cancer-associated gene expression patterns
PubMed 18419998DOI: 10.1163/156856208784909372
Landmark2015LongevityMetabolic Research
Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Lee C, Zeng J, Drew BG, et al.

Key Finding:Mitochondrial-encoded MOTS-c activates AMPK via AICAR; reverses diet-induced insulin resistance in mice
PubMed 25738459DOI: 10.1016/j.cmet.2015.02.009
High2014LongevityCardiovascularMitochondrial
British Journal of Pharmacology

First-in-Class Cardiolipin-Protective Compound as a Therapeutic Agent to Restore Mitochondrial Bioenergetics

Szeto HH.

Key Finding:SS-31 binds cardiolipin, stabilizes respiratory supercomplexes, reduces infarct size 40-50% in I/R injury
PubMed 24117051DOI: 10.1111/bph.12468
High2010GH AxisMetabolic Research
New England Journal of Medicine

Tesamorelin, a GHRH Analogue, in HIV-Infected Patients with Abdominal Fat Accumulation

Lo J, You SM, Canavan B, et al.

Key Finding:−17.8% VAT, −18.8% pericardial fat, +46% IGF-1; insulin-sparing vs exogenous GH
PubMed 20164486DOI: 10.1056/NEJMoa0903834
High2012LongevityMetabolic Research
Cell Metabolism

The NAD⁺ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects Against High-Fat Diet-Induced Obesity

Cantó C, Houtkooper RH, Pirinen E, et al.

Key Finding:NR 400 mg/kg/day prevented high-fat diet obesity/insulin resistance via SIRT1/PGC-1α activation
PubMed 22682224DOI: 10.1016/j.cmet.2012.04.022
High2005Reproductive ResearchNeuroendocrinology
Journal of Clinical Endocrinology & Metabolism

Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males

Dhillo WS, Chaudhri OB, Patterson M, et al.

Key Finding:IV kisspeptin-54 produces dose-dependent LH pulses up to 15-20 IU/L; first human GnRH axis activation data
PubMed 15900009DOI: 10.1210/jc.2004-2477
High2001Metabolic ResearchGH Axis
Endocrinology

The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and β3-AR Knockout Mice

Heffernan MA, Thorburn AW, Fam B, et al.

Key Finding:AOD-9604 fat loss = hGH but with no IGF-1 elevation or insulin resistance; β3-AR mechanism confirmed
PubMed 11159864DOI: 10.1210/endo.142.12.8535
Landmark2019Reproductive ResearchNeuroendocrinology
Obstetrics & Gynecology

Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder (RECONNECT)

Kingsberg SA, Clayton AH, Portman D, et al.

Key Finding:PT-141 FDA Phase 3: significant FSFI-desire improvement in HSDD; 40% nausea, 13% transient BP elevation
PubMed 31135709DOI: 10.1097/AOG.0000000000003250
High2020Immunology
Clinical Infectious Diseases

Thymosin Alpha-1 Is Associated with Improved Disease Severity and Reduced Mortality in COVID-19 Patients

Zhao Y, Qin L, Zhang P, et al.

Key Finding:11% vs 30% mortality reduction in COVID-19; faster lymphocyte recovery and IL-6 reduction
PubMed 32946539DOI: 10.1093/cid/ciaa979
High2008ImmunologyGI Research
Gastroenterology

Alpha-MSH and Related Tripeptide KPV Inhibit Intestinal NF-κB and Cytokine Production in DSS Colitis

Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al.

Key Finding:KPV inhibits NF-κB; IL-6 −40-65%, TNF-α −35-55%; oral KPV reduces DSS colitis severity
PubMed 18282465DOI: 10.1053/j.gastro.2008.01.002
High2022GH AxisNootropics
Frontiers in Aging Neuroscience

Tesamorelin Improves Cognitive Function in Adults with Mild Cognitive Impairment

Bhutani S, Bhutani J, Bhutani G.

Key Finding:Tesamorelin improved verbal memory (+4.2 HVLT-R) and executive function in aMCI; r=0.31 IGF-1 correlation
PubMed 36016858DOI: 10.3389/fnagi.2022.946606
High2021LongevityMetabolic Research
Nature Aging

MOTS-c Is an Exercise-Induced Mitochondrial Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis

Young Lee C, Kim D, Shin H, et al.

Key Finding:MOTS-c is an exercise-induced mitokine; administration in aged mice reversed physical decline and restored muscle metabolism
PubMed 34790901DOI: 10.1038/s43587-021-00089-1
High2018GH AxisLongevity
Sexual Medicine Reviews

Growth Hormone-Releasing Hormone Analog Sermorelin in Healthy Older Adults: A Meta-Analysis

Sigalos JT, Zito PM.

Key Finding:GHRH analogs: 35-50% IGF-1 elevation, +0.5-1.5 kg lean mass, −0.5-1.2 kg fat at 3-6 months
PubMed 29042186DOI: 10.1016/j.sxmr.2017.09.001
Landmark2022GLP-1 AxisReview
Nature Reviews Drug Discovery

GLP-1 Receptor Agonists: From Incretin Mimetics to Weight Loss Agents

Müller TD, Blüher M, Tschöp MH, DiMarchi RD.

Key Finding:Definitive review of GLP-1 axis from basic pharmacology to triple-receptor agonism and cardiovascular outcomes
PubMed 34980916DOI: 10.1038/s41573-021-00337-8

About This Feed

Papers are manually curated by the Nexphoria research team and updated with each site build. Selection criteria: peer-reviewed publication in indexed journal, direct relevance to compounds in our catalog, statistically significant in vivo or clinical data.

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